Translational-Oriented Quantitative Therapeutic Approaches:
A Concerted Effort

The Faculté de pharmacie of the Université de Montréal, in collaboration with CRM, PhysNum,
and CAMBAM is organizing a workshop from June 12th to 14^th at Jean-Coutu Pavilion.

The aim is to provide a dedicated place to discuss the most recent advances in quantitative
approaches in pharmacometrics.  A special emphasis will be placed on the translational effort of
these approaches to increase the predictability of drug-related therapeutic outcomes and facilitate clinical transferability. Several leading topics, such as quantitative systems pharmacology,
cutting-edge PK/PD modeling, mobile Health and mobile Therapeutics will be covered.

A Hands-on tutorial with SimBiology will be given on the second-half of the third day
of the workshop.

Agenda

MONDAY, 12 JUNE – Room S1-125 and S1-151 8h00 to 18h00

8:30 - 9:00       Breakfast

9:00 - 9:30       Welcome and Introduction
Fahima Nekka, Full Professor, Faculté de pharmacie, Université de Montréal
Daniel Lévesque, Vice-dean of Research, Faculté de pharmacie, Université de Montréal

9:30 - 10:05     Paolo Vicini, Senior Director at MedImmune (Cambridge, United Kingdom)
Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success

10:05 - 10:40  Daniele Ouellet, Senior Scientific Director at The Janssen Pharmaceutical Companies of 
Johnson & Johnson
Quantitative Decision Making in Translational Research

10:40 - 10:55   Break

10:55 - 11:30   Éric Masson, Executive Director Quantitative Clinical Pharmacology at AstraZeneca
(Waltham, Massachusetts)
Integrative Drug-Disease Modeling; Applications in Oncology

11:30 - 12:05   Brian Corrigan, Senior Director at Pfizer Pharmaceuticals
Challenges and Opportunities in the Development of Neurodegenerative Treatments:
The Role of Clinical Pharmacology and Pharmacometrics

12:05 - 13:30   Lunch

13:30 - 14:05   Alison Hill, Program for Evolutionary Dynamics, Harvard University
Modeling the impact of long-acting anti-HIV therapy

14:05 - 14:40  Steven Sanche, PhD. Candidate, Université de Montréal
Predicting the Virologic Response to Antiretrovirals Using a Mathematical Model of HIV

TUESDAY, 13 JUNE - S1-131 8h00 to 16h00 and S1-111 12h00 to 13h00

8:45 - 9:30      Breakfast

9:30 - 10:05    Andrea Edginton, Associate professor School of Pharmacy at University of Waterloo
Use of PBPK in clinical trial planning

10:05 - 10:40   Morgan Craig, Program for Evolutionary Dynamics, Harvard University
Lessons from modelling myelosuppression: why first principles matter?

10:40 - 10:55  Break

10:55 - 11:30  Philippe Robaey, Full professor, Dept of Psychiatry, Faculty of Medicine, University of Ottawa
What is to be Translated in Translational Research?

11:30 - 12:05  Sachin Sanduja, Chief Executive Officer at Rudraya, North Brunswick, New Jersey USA
Pharmacometrics-Based Decision Support Tools Facilitate mHealth and mTherapeutics Implementation – Opportunities and Challenges

12:05 - 13:30  Lunch

13:30 - 14:05  Jean-Francois Marier, Senior Vice President Canada, Consulting Services, Certara Critical Path for Tuberculosis Regimens

14:05 - 14:40  Ema Ferreira, Vice-Dean Undergraduate Studies, Faculté de pharmacie, Université de Montréal
Measuring drugs in breastmilk: can a model help predict infant drug exposure?

WEDNESDAY, 14 JUNE - Room S1-111 8h00 to 16h00 and S1-131 8h00 to 18h00

9:00 - 9:30      Breakfast

9:30 - 10:00    Guillaume Bonnefois, Associate Scientist, inVentiv Health Clinical
Implementation of a mobile health tool for the clinical decision of Attention Deficit Disorder with or without Hyperactivity

10:00 - 10:30  Olivier Barrière, Senior Scientist, inVentiv Health Clinical 
Automation of common Pharmacometric Activities

10:30 - 11:00   Jun Li, Assistant professor, Faculté de pharmacie, Université de Montréal
At the crossroad of mathematics and pharmacutical sciences: emerging pharmacology as a new hard science

11:00 - 11:30  Denis DeBlois, Full professor, Faculté de pharmacie, Université de Montréall 
Drug Research and Education Programs at UdeM

11:30 - 11:50  Discussion

11:50 - 12:00  Closing Remarks and Farewell

12:00 - 13:00  Lunch

13:00 - 17:00  
Brusher Jerry& Fulden Buyukozturk,
Tutorial:  Hands-on Tutorial with SimBiology
Outline of the tutorial of SimBiology 

�.      The Introduction to SimBiology

-          Overview of MATLAB and SimBiology

-          Navigating the SimBiology desktop environment

-          Working with a SimBiology project

�.      Building and Simulating Mechanistic Models - using Target Mediated Drug Disposition
(TMDD) model as an example

-          Overview of the building blocks and modeling architecture

-          Building models using the SimBiology block diagram editor

-          Configuring simulation-related settings such as solvers, tolerances, sampling time, etc.

-          Interactively exploring model dynamics and sensitivity using parameter sliders

-          Simulating hypothetical scenarios and dosing schedules

�.      Data Fitting and Implementing Traditional Compartmental PK/PD Workflows – using 1 compartment PK model as an example

-          Importing and visualizing data

-          Performing non-compartmental analysis (NCA)

-          Estimating parameters using nonlinear regression and population-based methods

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