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Translational-Oriented Quantitative Therapeutic Approaches:
Concerted Effort

The Faculté de pharmacie of the Université de Montréal, in collaboration with CRM, PhysNum,
and CAMBAM is organizing a workshop from June 12th to 14th
.

The aim is to provide a dedicated place to discuss the most recent advances in quantitative
approaches in pharmacometrics.  A special emphasis will be placed on the translational effort of
these approaches to increase the predictability of drug-related therapeutic outcomes and facilitate clinical transferability. Several leading topics, such as quantitative systems pharmacology,
cutting-edge PK/PD modeling, mobile Health and mobile Therapeutics will be covered
.

A Hands-on tutorial with SimBiology will be given on the second-half of the third day
of the workshop.

Agenda

MONDAY, 12 JUNE

8:30 - 9:00      Breakfast

9:00 - 9:30      Welcome and Introduction
Fahima Nekka, Full Professor, Faculté de pharmacie, Université de Montréal
Céline Fiset, Vice-dean of Research, Faculté de pharmacie, Université de Montréal

9:30 - 10:05    Paolo Vicini, Senior Director at MedImmune (Cambridge, United Kingdom)
Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success

10:05 - 10:40  Daniele Ouellet, Senior Scientific Director at The Janssen Pharmaceutical Companies of 
Johnson & Johnson
Quantitative Decision Making in Translational Research

10:40 - 10:55  Break

10:55 - 11:30  Éric Masson, Executive Director Quantitative Clinical Pharmacology at AstraZeneca
(Waltham, Massachusetts)
Integrative Drug-Disease Modeling; Applications in Oncology

11:30 - 12:05  Brian Corrigan, Senior Director at Pfizer Pharmaceuticals
Challenges and Opportunities in the Development of Neurodegenerative Treatments:
The Role of Clinical Pharmacology and Pharmacometrics

12:05 - 13:30  Lunch

13:30 - 14:05  Alison Hill, Program for Evolutionary Dynamics, Harvard University
Modeling the impact of long-acting anti-HIV therapy

14:05 - 14:40  Philippe Robaey, full professor, Dept of Psychiatry, Faculty of Medicine, University of Ottawa
What is to be Translated in Translational Research?

TUESDAY, 13 JUNE

8:45 - 9:30      Breakfast

9:30 - 10:05    Andrea Edginton, Associate professor School of Pharmacy at University of Waterloo
Use of PBPK in clinical trial planning

10:05 - 10:40  Morgan Craig, Program for Evolutionary Dynamics, Harvard University
Improving the Use of G-CSF During Chemotherapy Using Physiological Mathematical Modelling: A Quantitative Systems Pharmacology Approach

10:40 - 10:55  Break

10:55 - 11:30  Steven SanchePhD. Candidate, Université de Montréal
Predicting the Virologic Response to Antiretrovirals Using a Mathematical Model of HIV

11:30 - 12:05  Sachin Sanduja, Chief Executive Officer at Rudraya, North Brunswick, New Jersey USA
Pharmacometrics-Based Decision Support Tools Facilitate mHealth and mTherapeutics Implementation – Opportunities and Challenges

12:05 - 13:30  Lunch

13:30 - 14:05  Jun Li, assistant professor, Faculté de pharmacie, Université de Montréal
Title TBD

14:05 - 14:40  Ema Ferreira, Vice-Dean Undergraduate Studies, Faculté de pharmacie, Université de Montréal
Title TBD

 

WEDNESDAY, 14 JUNE

9:00 - 9:30      Breakfast

9:30 - 10:05    Guillaume Bonnefois, Associate Scientist, inVentiv Health Clinical
Implementation of a mobile health tool for the clinical decision of Attention Deficit Disorder with or without Hyperactivity

10:05 - 10:40  Olivier Barrière, Senior Scientist, inVentiv Health Clinical 
Title: TBD

10:40 - 11:15  PO Tremblay, Director of Pharmacometrics, inVentiv Health Clinical 
Pharmacometrics at inVentiv Health Clinical: When the Training is Central in Academia and Industry

11:15 - 11:45  Discussion

11:45 - 12:00  Closing Remarks and Farewell

12:00 - 13:00  Lunch

13:00 - 17:00 Brusher Jerry& Fulden Buyukozturk, Mathworks
Tutorial:  Hands-on Tutorial with SimBiology
Outline of the tutorial of SimBiology 

         The Introduction to SimBiology

-       Overview of MATLAB and SimBiology

-       Navigating the SimBiology desktop environment

-       Working with a SimBiology project

         Building and Simulating Mechanistic Models - using Target Mediated Drug Disposition
(TMDD) model as an example

-       Overview of the building blocks and modeling architecture

-       Building models using the SimBiology block diagram editor

-       Configuring simulation-related settings such as solvers, tolerances, sampling time, etc.

-       Interactively exploring model dynamics and sensitivity using parameter sliders

-       Simulating hypothetical scenarios and dosing schedules

         Data Fitting and Implementing Traditional Compartmental PK/PD Workflows – using 1 compartment PK model as an example

-       Importing and visualizing data

-       Performing non-compartmental analysis (NCA)

-       Estimating parameters using nonlinear regression and population-based methods

Version française

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